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Frontera Biotecnol%u00f3gica | N%u00b0 29 septiembre-diciembre 2024 82ISSN: 2448-8461El impacto de los pl%u00e1sticos convencionales y su fragmentaci%u00f3n a micropl%u00e1sticos representa un alto riesgo a la salud humana. Aunado el problema actual de contaminaci%u00f3n ambiental y los efectos en el ecosistema. La b%u00fasqueda de encontrar un sustito de los pl%u00e1sticos petroqu%u00edmicos es inminente, por lo que el PHB presenta un panorama prometedor. Sin embargo, la producci%u00f3n a nivel industrial es reducida. Los m%u00e9todos de producci%u00f3n actuales presentan bajos rendimientos y los procesos de extracci%u00f3n y purificaci%u00f3n aun representan una problem%u00e1tica a resolver. A pesar de ello, se han ido presentando diferentes posibilidades para hacer el proceso m%u00e1s redituable y amigable con el ambiente, siendo uno de los enfoques principales en los %u00faltimos a%u00f1os. En definitiva, el PHB no es un villano, es un h%u00e9roe en potencia que requiere adecuaciones en su camino a reemplazar los pl%u00e1sticos.Esta investigaci%u00f3n fue apoyada por el Centro de Investigaci%u00f3n en Biotecnolog%u00eda Aplicada (CIBA-IPN Unidad Tlaxcala), el Instituto Polit%u00e9cnico Nacional (Proyecto SIP20242318) y el Consejo Nacional de Humanidades, Ciencia y Tecnolog%u00eda (Becario CONAHCYT 1268180) Conclusi%u00f3nAgradecimientosChamas A, Moon H, Zheng J, Qiu Y, Tabassum T, Jang J H, AbuOmar M, Scott S L, Suh S (2020). Degradation Rates of Plastics in the Environment. ACS Sustainable Chemistry & Engineering, 8(9), 3494%u20133511. https://doi.org/10.1021/acssuschemeng.9b06635Cox KD, Covernton GA, Davies HL, Dower JF, Juanes F, Dudas SE (2019). Human Consumption of Microplastics. Environmental Science & Technology, 53(12), 7068%u20137074. https://doi.org/10.1021/acs.est.9b01517Dey P, Rangarajan V (2017). Improved fed-batch production of high-purity PHB (poly-3 hydroxy butyrate) by Cupriavidus necator (MTCC 1472) from sucrose-based cheap substrates under response surface-optimized conditions. 3 Biotech, 7(5), 310. https://doi.org/10.1007/s13205-017-0948-6Elhacham E, Ben-Uri L, Grozovski J, Bar-On YM, Milo R (2020). Global human-made mass exceeds all living biomass. Nature, 588(7838), 442%u2013444. https://doi.org/10.1038/s41586-020-3010-5Fuessl A, Yamamoto M, Schneller A (2012). Opportunities in Bio-Based Building Blocks for Polycondensates and Vinyl Polymers. In Polymer Science: A Comprehensive Reference (pp. 49%u201370). Elsevier. https://doi.org/10.1016/B978-0-444-53349-4.00132-1Helinski OK, Poor CJ, Wolfand JM (2021). Ridding our rivers of plastic: A framework for plastic pollution capture device selection. Marine Pollution Bulletin, 165, 112095. https://doi.org/10.1016/j.marpolbul.2021.112095Jayarathna S, Andersson M, Andersson R (2022). Recent Advances in Starch-Based Blends and Composites for Bioplastics Applications. Polymers, 14(21), 4557. https://doi.org/10.3390/polym14214557Kanzariya R, Gautam A, Parikh S, Shah M, Gautam S (2023). Formation of polyhydroxyalkanoates using agro and industrial waste as a substrate %u2013 a review. Biotechnology and Genetic Engineering Reviews,1%u201340. https://doi.org/10.1080/02648725.2023.2165222Agarwal S (2021). Major factors affecting the characteristics of starch based biopolymer films. European Polymer Journal, 160,110788. https://doi.org/10.1016/j.eurpolymj.2021.110788Albuquerque PBS, Malafaia CB (2018). Perspectives on the production, structural characteristics and potential applications of bioplastics derived from polyhydroxyalkanoates. International Journal of Biological Macromolecules, 107,615%u2013625. https://doi.org/10.1016/j.ijbiomac.2017.09.026Angnunavuri PN, Attiogbe F, Mensah B (2023). Particulate plastics in drinking water and potential human health effects: Current knowledge for management of freshwater plastic materials in Africa. Environmental Pollution, 316,120714. https://doi.org/10.1016/j.envpol.2022.120714Arcos-Hernandez M V, Laycock B, Pratt S, Donose B C, Nikoli%u0107 M A L, Luckman P, Werker A, Lant P A (2012). Biodegradation in a soil environment of activated sludge derived polyhydroxyalkanoate (PHBV). Polymer Degradation and Stability, 97 (11), 2301%u20132312. https://doi.org/10.1016/j.polymdegradstab.2012.07.035Aytan %u00dc, Ba%u015fak Esensoy F, %u015eent%u00fcrk Y, G%u00fcven O, Karao%u011flu K, Erbay M (2023). Plastic occurrence in fish caught in the highly industrialized Gulf of %u0130zmit (Eastern Sea of Marmara, T%u00fcrkiye). Chemosphere, 324, 138317. https://doi.org/10.1016/j.chemosphere.2023.138317Behera S, Priyadarshanee M, Vandana Das S (2022). Polyhydroxyalkanoates, the bioplastics of microbial origin: Properties, biochemical synthesis, and their applications. Chemosphere, 294, 133723. https://doi.org/10.1016/j.chemosphere.2022.133723Bergmann M, Almroth B C, Brander S M, Dey T, Green D S, Gundogdu S, Krieger A, Wagner M, Walker T R (2022). A global plastic treaty must cap production. Science, 376 (6592), 469%u2013470. https://doi.org/10.1126/science.abq0082REFERENCIA