Page 19 - Demo

septiembre-diciembre 2024 Frontera Biotecnol%u00f3gica | N%u00b0 29 19ISSN: 2448-8461Las isoflavonas son conocidas como fitoestr%u00f3genos y presentan propiedades farmacol%u00f3gicas como cardioprotectores, antidiab%u00e9ticos, anticancer%u00edgenos y neuroprotectores. En la b%u00fasqueda de potenciales agentes neuroprotectores, se evalu%u00f3 una serie de isoflavonas preniladas derivadas de la isoflavona natural formononetina para determinar su actividad inhibidora in vitro sobre la enzima acetilcolinesterasa. Los resultados muestran que las isoflavonas presentan moderada a d%u00e9bil actividad siendo la formononetina con mayor efecto inhibitorio (CI50 = 100 %u00b5M) con respecto a tacrina (CI50 = 14.79 %u00b5M). Esto sugiere que la presencia de un grupo hidroxilo en posici%u00f3n C-7 del n%u00facleo de isoflavona favorece el efecto inhibitorio mientras que, la adici%u00f3n de un grupo prenilo lineal o ciclizado disminuye la actividad. Por tanto, formononetina es un buen candidato para el dise%u00f1o de nuevos inhibidores de acetilcolinesterasa relacionados al tratamiento de enfermedades neurodegenerativas.Palabras clave: isoflavonas preniladas, formononetina, acetilcolinesterasa, enfermedades degenerativasIsoflavones are known phytoestrogens and have pharmacological properties such as cardioprotective, antidiabetic, anticancer, and neuroprotective. In the research for potential neuroprotective agents, a series of prenylated isoflavones derived from the natural isoflavone formononetin were evaluated for their in vitro inhibitory activity against the enzyme acetylcholinesterase. The results displayed that isoflavones showed moderate to weak activity where formononetin had the greatest inhibitory effect (CI50 = 100 %u00b5M) concerning tacrine (CI50 = 14.79 %u00b5M). This suggests that the presence of a hydroxyl group at C-7 position of the isoflavone core favors the inhibitory effect, while the addition of a linear or cyclized prenyl group decreases the activity. Therefore, formononetin is a good candidate for designing new acetylcholinesterase inhibitors related to treating neurodegenerative diseases.Keywords: prenylated isoflavones, formononetin, acetylcholinesterase, Degenerative diseasesRESUMEN ABSTRACT